View post tag: finished View post tag: News by topic Authorities View post tag: Motor View post tag: Naval Back to overview,Home naval-today USS Rhode Island’s Motor Generator Restoration Finished View post tag: USS Rhode Island USS Rhode Island’s Motor Generator Restoration Finished Share this article Portsmouth Naval Shipyard (PNSY) completed restoration of the motor generator set for the Ohio-class ballistic-missile submarine USS Rhode Island (SSBN 740) three days ahead of schedule Feb. 23.PNSY was already restoring a motor generator set for Rhode Island, a process that typically takes 12 to 18 months, when Trident Refit Facility (TRF) Kings Bay informed the shipyard they wanted to replace the motor generator set during the upcoming availability – 10 months earlier than the regularly scheduled overhaul. To support the timeline of this change, TRF Kings Bay required the completed MG set on site by Feb. 26.Engineering and production reprioritized their work and the MG team worked through a holiday weekend snowstorm and completed full machine assembly and setup for final testing. Testing was completed successfully and the motor generator was shipped to TRF Kings Bay, arriving three days early.PNSY is the Navy’s Designated Overhaul Point for 500 kilowatt motor generator set. Motor generator overhaul at Portsmouth Naval Shipyard remains a vital element of the Navy’s submarine maintenance industrial base. As a field activity of Naval Sea Systems Command, PNSY is committed to maximizing the material readiness of the fleet by safely delivering first-time quality work, on time, and on budget.[mappress mapid=”15389″]Image: US Navy View post tag: Navy View post tag: americas View post tag: Generator View post tag: Restoration March 13, 2015
As school responsibilities wrap up and summer break begins, youth now have more time for livestock projects and hands-on learning.Through University of Georgia Cooperative Extension, Georgia 4-H offers educational opportunities in programs that challenge youth with real-life issues as they learn responsibility through raising, showing and evaluating livestock. These projects provide students the opportunity to practice and acquire new knowledge in the fields of animal science, business, time management and leadership.With many extra-curricular activities sidelined, youth have more time for livestock-related tasks like showmanship practice, developing their record book and fine-tuning their animal show entries. Educational ResourcesWhile social distancing, youth have been introduced to a new way of virtual learning. To ensure that dedication and enthusiasm continue to grow for livestock programs, Georgia 4-H has begun offering instruction online as well as providing various resources, which include:Dairy farm tour videos: origin.americandairy.com/news-and-events/dairy-diary/dairy-farming/virtual-farm-tours-while-youre-stuck-at-home.stmlHorse judging from home videos by Middle Tennessee State University and University of Tennessee Extension: www.youtube.com/watch?v=bEJjxuN56N4&list=PLNXP12SwUle1PuvPAfKXOHqIXeBqM0g1rBasic horse riding exercises video by Louisiana State University Extension: www.youtube.com/watch?v=R05rTHKmhAcUGA Extension Bulletin 1234, “Dairy Judging Terminology: A Guide to Saying What She is and Not What She Isn’t”: t.uga.edu/61EUGA Extension Bulletin 1401, “Evaluating Common Equine Performance Classes”: t.uga.edu/61FUGA Extension Bulletin 1427, “Is Your Heifer Fit to Show? A Guide to Fitting and Showing Dairy Animals”: t.uga.edu/61GA list of more online resources is available at georgia4h.org/about-us/resources/activity-resources/#livestock.Virtual CompetitionsGeorgia 4-H is also continuing with statewide contests by adapting them into virtual competitions. These events allow youth to continue to challenge their knowledge, receive recognition for their accomplishments and learn life and leadership skills.State virtual horse show educational contests and a state virtual livestock judging contest will be held for 4-H members in grades 4 through 12, who can register and get more details by contacting 4-H staff at their local Extension office. The deadline to register online for livestock judging is June 10 and the online deadline for entering the horse contests is June 15. Youth can prepare by reviewing the additional information available in the Georgia 4-H State Horse Show Rules and Regulations and the Georgia 4-H Livestock Judging Educational Resources.For more information on these contests, please contact Georgia 4-H Livestock Extension Specialist Heather Shultz at [email protected] addition to state contests, various counties and districts have created opportunities for youth to demonstrate their learned skills within their peer groups. Details can be obtained by emailing or calling staff at UGA Extension offices. Find local contact information at extension.uga.edu/county-offices.To learn more about the Georgia 4-H Livestock Program, visit georgia4h.org/livestock.Georgia 4-H empowers youth to become true leaders by developing necessary life skills, positive relationships and community awareness. As the largest youth leadership organization in the state, 4-H reaches more than 242,000 people annually through the University of Georgia Cooperative Extension offices and 4-H facilities. For more information, visit georgia4h.org.
Could there be a leak? US diplomatic cables seen by The Washington Post earlier said that officials were concerned about inadequate safety standards related to researchers’ handling of SARS-like bat coronaviruses in the high-security lab.The institute has said it received samples of the then-unknown virus on December 30, determined the viral genome sequence on January 2 and submitted information on the pathogen to the WHO on January 11.Shi Zhengli, one of China’s leading experts on bat coronaviruses and deputy director of the Wuhan P4 lab, said she would “bet her life that [the new coronavirus] had nothing to do with the lab”, according to Chinese state media.And in an interview with Scientific American, Shi said the SARS-CoV-2 genome sequence did not match any of the bat coronaviruses her laboratory had previously collected and studied. What do its researchers do? Work by the lab’s scientists helped to shed light on the COVID-19 pathogen in the early days of the outbreak in Wuhan.In February, they published work concluding that the new virus shared a 79.6 percent sequence identity to the SARS coronavirus, and that it was 96 percent identical at the whole-genome level to a coronavirus found in bats.The lab’s researchers had already conducted extensive investigations on the links between bats and disease outbreaks in China, and had highlighted the need to prepare for viruses potentially spreading out of their natural reservoirs into human communities.Scientists think COVID-19 originated in bats and could have been transmitted to people via another mammal like a pangolin, but there is no definitive answer so far. The Chinese laboratory accused by top American officials of being the source of the coronavirus pandemic conducts research on the world’s most dangerous diseases.US President Donald Trump and Secretary of State Mike Pompeo have both claimed that there is evidence the pathogen came from the lab in Wuhan — the city where the disease was first detected late last year.But the World Health Organization said Washington had offered no evidence to support the “speculative” claims, and scientists believe the coronavirus jumped from animals to humans, possibly at a Wuhan market selling wild animals. Topics : The top US epidemiologist Anthony Fauci has echoed the WHO’s statement, telling National Geographic that all evidence so far “strongly indicates” a natural origin.China has strongly denied the allegations, but speculation and conspiracy theories have persisted.Here are some key questions about the Wuhan Institute of Virology: What do scientists know about the virus? Researchers have noted that while there is no proof for the lab accident theory, there is also no clear evidence that the virus came from the Wuhan market.A study by a group of Chinese scientists published in The Lancet in January found that the first COVID-19 patient had no connection to the market, and neither did 13 of the first 41 confirmed cases.Professor Leo Poon of The University of Hong Kong said the scientific community’s consensus was that the virus is not human-made.”We need to look at the origin of this virus. It is important, because from a public health point of view, we want to know how it happened, and [if we can] learn from this,” he said.David Heymann, professor of infectious disease epidemiology at the London School of Hygiene and Tropical Medicine, added: “We have a hypothesis that it came from a live animal market, and I haven’t seen anybody provide evidence that shows to the contrary.” What does it handle? The Wuhan institute houses the largest virus bank in Asia, which preserves more than 1,500 strains.The complex contains Asia’s first maximum-security lab equipped to handle Class 4 pathogens (P4) such as Ebola.The 300-million-yuan ($42 million) P4 lab opened in 2018. A P3 lab has been in operation since 2012.While the US intelligence community said it had concluded the coronavirus was not human-made, it added that it would continue to investigate if the outbreak started from contact with infected animals or from “an accident” at the Wuhan lab.
Share Facebook Twitter Google + LinkedIn Pinterest Scientists at The Ohio State University have successfully tested a new chemical to control mosquitoes, including the ones that spread Zika, and it comes from a traditional medicinal plant found only in Madagascar.Peter Piermarini and Liva Rakotondraibe said a bark extract from Cinnamosma fragrans, a small tree commonly called mandravasarotra, made the mosquitoes in their study buzz off. It repelled the flying adults from a distance, which kept them from landing and feeding on blood. And it killed the larvae and adults upon contact.“What’s exciting is that it’s a natural product,” said Piermarini, an associate professor of entomology in Ohio State’s College of Food, Agricultural, and Environmental Sciences (CFAES). “We’re taking advantage of something plants have been doing for millions of years” — evolving chemicals to defend themselves from insects — “to hopefully get a leg up on mosquitoes.”In recent years, public health agencies have been scrambling for new ways to fight the biters. That’s partly because more and more mosquitoes have become resistant to common insecticides, and partly because of the spread of mosquito-borne diseases, Zika being one of them.The U.S. Centers for Disease Control and Prevention reported in May that illnesses from infected mosquito, tick and flea bites tripled in the United States during the 13 years from 2004 to 2016, with more than 640,000 total cases reported.The Ohio State scientists said the new chemical isn’t ready to be turned into a commercial product just yet, but has lots of potential to become one.Of note, they said the chemical works equally well on normal mosquitoes and on mosquitoes that are resistant to common insecticides. So as an added weapon in a mosquito-fighting arsenal, it could slow the development of resistance to other insecticides.“It appears to act through a novel mechanism that conventional insecticides currently don’t exploit,” Piermarini said.Mandravasarotra is one of the more than 12,000 plant species found in Madagascar, of which 8 out of 10 are endemic: they don’t grow naturally anywhere else. Parts of the tree have long been used in folk medicine in the country, and more recently, as a source of essential oil for aromatherapy.“It’s very fragrant,” Piermarini said, showing a piece of the bark. “It has a black pepper-like scent.”Piermarini is an expert on the biology of mosquitoes. Based at CFAES’s Wooster campus, his work includes developing new insecticides and repellents.Finding, tapping into plants that help peopleRakotondraibe is an assistant professor in Ohio State’s College of Pharmacy in Columbus, where he focuses on medicinal chemistry and pharmacognosy (the study of medicines from natural sources).Originally from Madagascar, Rakotondraibe has a special interest in the country’s diverse medicinal plants, mandravasarotra included, and when he came to Ohio State in 2013, he brought with him some of the compounds that he had isolated from those plants. He’s testing the compounds for treating diseases including malaria and cancer.A mutual colleague, who knew of Piermarini’s and Rakotondraibe’s research interests, suggested the two team up.For their study, the scientists tested the mandravasarotra bark extract on Aedes aegypti, one of the most widespread mosquito species globally and the primary carrier of the Zika, dengue, yellow fever and chikungunya viruses. All four viruses are spreading in the United States and in other parts of the world, possibly due to climate change, and can cause serious diseases in humans.Through their research, the scientists found that mandravasarotra bark contains a chemical called cinnamodial, and that’s what affected the mosquitoes. Cinnamodial is a sesquiterpene, a group of plant chemicals common in resins and in essential oils.The scientists further discovered that cinnamodial activates a type of sensory receptor in the mosquito called TRPA1. Located in nerve cells on the antennae and mouth parts, TRPA1 receptors help mosquitoes detect heat and dangerous chemicals in their environments — things that could damage their genes or their bodies, things they should try to avoid.Piermarini said cinnamodial is “probably quite irritating to the mosquito,” which is likely why it’s repellent. He said a similar receptor in humans detects spicy foods.“You can envision what a mosquito must be experiencing (from cinnamodial) if you think about putting a big spoonful of wasabi in your mouth, and having a reaction that intense,” Piermarini said. “You can get a sense of why they don’t like it.”It’s less clear, though, why mosquitoes die from cinnamodial, at least after having direct contact with it. Piermarini said his best guess is that it’s due to an aldehyde, one of the molecules that make up the compound.“Aldehydes tend to be fairly noxious chemicals that can cause a lot of damage to cells and DNA,” Piermarini said. He thinks the compound does exactly that, to the point it kills the mosquito.In some of their tests, the scientists sprayed the bark extract on adult mosquitoes. In other tests, they added it to the water of the swimming larvae.Mosquitoes want to avoid itIn both cases, Piermarini said, the mosquitoes’ TRPA1 receptors “couldn’t do them any good because they couldn’t avoid the chemical, and it ended up killing them, unfortunately for them.”But it was good news for the scientists.The findings mean “we’ve got a compound that shows good activity,” a strong candidate for further development, Rakotondraibe said. “That’s exciting.”Next, Rakotondraibe will begin to try to improve the compound, tweaking it at a molecular level to make it more stable and potent.He’ll try to isolate other new chemicals from mandravasarotra bark, too, and if he succeeds, Piermarini will test them in a similar fashion to see their effects on mosquitoes.Together, the scientists will simply try to better understand what the chemicals do to mosquitoes: What makes them toxic and repellent?“Ultimately, if you want to control mosquitoes, you need to have a really comprehensive toolbox,” Piermarini said. “You don’t want to be limited to just one tool, because they’re going to be evolving resistance to it.“So the more tools we develop, the less we have to rely on a single one, and that can slow down the evolution of resistance because you’re attacking the problem with multiple strategies instead of relying on a silver bullet where you put a lot of pressure for resistance to evolve.”The study appeared in the journal PLOS Neglected Tropical Diseases.Researchers on the study also included Edna Alfaro Inocente, Marguerite Shaya and Nuris Acosta, all of CFAES’s Department of Entomology.The study was funded by the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health; Ohio State’s Public Health Preparedness for Infectious Diseases Program; the SEEDS competitive grants program of CFAES’s Ohio Agricultural Research and Development Center (OARDC); and state and federal funds appropriated to OARDC.
Source:http://agencia.fapesp.br/defense-against-intestinal-infection-in-organism-is-affected-by-prostaglandin-esub2-sub/29180/ Reviewed by James Ives, M.Psych. (Editor)Nov 15 2018The treatment of intestinal infections caused by some strains of the bacterium Escherichia coli, present in unsanitized or contaminated foods, may have a new ally.A study published in PNAS reports that the inhibition of prostaglandin E2 (PGE2), a lipid mediator released during the process of infected cell clearance (efferocytosis) in the intestine, enhanced the ability of mice to combat infectious colitis.”Tissue cell death is intense during a bacterial infection. Many immune cells recruited to the site of the infection also die. We found that during the removal of dead and infected cells, a process called efferocytosis, there was an increase in the release of proteins and of the lipid mediator prostaglandin E2. However, the presence of PGE2 impaired the differentiation of Th17 [or T helper 17] cells, lymphocytes that play a key role in the resolution of intestinal infections,” said Alexandra Ivo de Medeiros, a professor at São Paulo State University’s School of Pharmaceutical Sciences (FCF-UNESP) in Araraquara, Brazil, and principal investigator for the study.To prove this hypothesis, the researchers inhibited the production of PGE2 using nonsteroidal anti-inflammatory drugs such as indomethacin and ibuprofen. The inhibition of PGE2 resulted in increased differentiation of Th17 cells.”Th17 cells play a key role in resolving bacterial intestinal infection by promoting the recruitment of inflammatory cells and the production of natural antibiotics,” Medeiros told.The study funded by São Paulo Research Foundation -FAPESP also showed that blocking only one PGE2 receptor, EP4, reversed the suppressive effect of PGE2 on the differentiation of Th17 cells.Different functions”Prostaglandin E2 can perform different functions depending on the type of cell and receptor involved. Our use of the EP4 prostaglandin receptor antagonist enhanced the resolution of infectious colitis,” said Naiara Naiana Dejani, first author of the article. Dejani earned her PhD with a scholarship from FAPESP.Another finding of the study was that inhibiting prostaglandin synthesis or signaling by treatment with the EP4 antagonist L-161,982 favored the expression of defensins, which are considered natural antibiotics, in the colon.Related StoriesResearch sheds light on sun-induced DNA damage and repairAn active brain and body associated with reduced risk of dementiaNew study reveals ‘clutch’ proteins responsible for putting T cell activation ‘into gear'”The use of a specific antagonist of the PGE2 receptor, such as the EP4 receptor antagonist, offers advantages in terms of an auxiliary proposal for the treatment of infectious colitis. Nonselective nonsteroidal anti-inflammatory drugs, or NSAIDs, such as indomethacin and ibuprofen, are inexpensive but can cause adverse events that have been well described in the literature,” Dejani said.Despite the protective effect of Th17 cells in bacterial infection, these same cells may cause chronic inflammation and autoimmune disease, so while the discovery points to an important potential ally of antibiotics in treating infections, a buildup of Th17 cells in the intestine could result in future complications.InfectionThe study resulted from a project led by Medeiros with a Young Investigator grant from FAPESP. Two of its authors besides Dejani also received scholarships from FAPESP: Allan Botinhon Orlando and Felipe Fortino Verdan.Carlos Henrique Serezani, a researcher at Vanderbilt University in Nashville, Texas (USA), also participated in the collaboration. Serezani was Dejani’s supervisor during a FAPESP-funded research internship abroad that resulted in the publication of an article in the journal Diabetes.In the experiment, mice were orally infected with a bacterium (Citrobacter rodentium) that mimics infection by E. coli in humans. After 24 hours, they began receiving a one-week treatment. Indomethacin was administered every two days to one group, while a second group received a daily dose of L-161,982 (the EP4 antagonist). Controls were given an innocuous substance.Analysis of the intestine in all groups at the end of the treatment showed that the use of an EP4 antagonist may be a promising strategy for the auxiliary treatment of infectious colitis. However, further research is required to show whether combining the EP4 antagonist and antibiotic therapy improves the resolution of this bacterial infection.
With the growth of online and mobile technologies, social media has emerged as a powerful tool for sharing information during extreme weather events. Provided by University at Albany Explore further Assistant Professors Sam Jackson (left) and Amber Silver recently launched CEHC’s Crisis Informatics Lab. Credit: Patrick Dodson Just last month, Hurricane Florence went viral as it pummeled the Carolinas. People who rode out the storm turned to platforms like Facebook, Twitter and YouTube to share photos and videos from the ground. Others were simply using social media for forecast and evacuation updates, as well as to stay in contact with impacted family and friends.The online chatter had Amber Silver’s full attention.Crisis Informatics LabSilver, an assistant professor at the College of Emergency Preparedness, Homeland Security and Cybersecurity, established the Crisis Informatics Lab on campus to research the usage of social media around disasters.Launched this month, Silver is the lab’s principal investigator, working in collaboration with CEHC colleague Sam Jackson, a newly hired assistant professor who studies politics and activism online in the United States.The lab’s primary focus is extreme weather events.”Social media is a powerful tool. It gives us all a platform to be our own news creators,” said Silver. “We are focused on what motivates people to share information about extreme weather. Also, if sharing this information influences decision making, in the days leading up, during and after the storm passes.””I am deeply passionate about weather and risk communication – our lab is combining both,” she added.Silver credits Hurricane Sandy in 2013 as the first time Twitter was used by first responders to communicate with people who were in need of assistance. Even before the storm hit, local officials were turning to digital platforms to share information in real-time.Last August, Twitter once again became a life-saving tool as Hurricane Harvey flooded Texas. First responders located people in need of rescue through the hashtag #HarveySOS.There’s value after the storm passes too, according to Silver.”People are turning to social media to connect with others who have gone through a similar experience to them,” Silver said. “Some find it soothing to share their story. It’s a way of healing.”Credibility is something Silver is observing closely.”Trust on social media is very person-dependent,” Silver said. “Some people will only follow official accounts, while others have a general distrust for government and the news media. It’s important for community leaders to be good stewards and moderate the conversation.”Florence TweetsTo understand Twitter’s usage around Hurricane Florence, Silver, through the Crisis Informatics Lab, used keyword searches to collect tweets from 6 million accounts that made mention of the storm.Accounts located in the Carolinas, Virginia, Georgia and Florida received an at-mention from the lab with a link to a brief questionnaire. Silver hopes to collect and interpret responses within the next few months.”Our goal is make practical recommendations that will improve the effectiveness of social media communication during crisis situations; this questionnaire is going to provide us with some valuable insight,” Silver said. Citation: Crisis informatics lab tracks extreme weather on social media (2018, October 24) retrieved 17 July 2019 from https://phys.org/news/2018-10-crisis-informatics-lab-tracks-extreme.html Social media provides critical information missed by FEMA This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
When your medications are the news This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Bish Clow, 22, who studies Product Design and Technology, has created Chill—a flexible insulated pouch to store medication at refrigerator temperature.The aim of the product is to give people the freedom to enjoy trips away from home without worrying about how to keep their medication cold.Bish first came across this problem after his girlfriend was diagnosed with MS at the age of 21.Bish said she was offered a variety of medications, some of which needed to be kept refrigerated.He thought this could cause issues especially while traveling and he wanted to create a product to help.He said: “Millions of people all around the world live with conditions requiring a medication which must be stored at refrigerator temperatures for them to remain effective. These drugs can include hormone treatments and insulin.”This poses the issue of always having access to a fridge to keep the medication at the right temperature. People are given these medications without having specialised equipment to correctly store it.”The wallet can store a wide range of drugs and drug delivery systems within a temperature range of 2-8°C.The wallet uses a compact refrigeration system to keep the contents at a stable temperature and the device runs off an internal battery which lasts for several hours.Bish said during his research he spoke to people who rely on refrigerated medications for conditions such as rheumatoid arthritis and cystic fibrosis.He asked them how they kept their drugs cool while away from home.”These people said it required a lot of planning and structure that can often detract from the experience of going away and they can’t always be as spontaneous as they might want to be,” he said.”Some users would sometimes rather miss doses of medication than try to attempt taking it with them. Individuals can feel like prisoners of their own medication.”Bish said that as well as giving people more freedom, the product also has the potential to help save healthcare providers money as the medications won’t be wasted from them being stored incorrectly. A student from Loughborough University has designed a portable wallet to keep medication cool after being inspired by his girlfriend who was diagnosed with Multiple Sclerosis (MS). Credit: Loughborough University Provided by Loughborough University Explore further Citation: Student creates portable wallet to keep medication cool after being inspired by girlfriend’s story (2019, June 14) retrieved 17 July 2019 from https://phys.org/news/2019-06-student-portable-wallet-medication-cool.html